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Magnetic Resonance Imaging of Heart Regeneration

发布日期:2016-06-16 16:28:36      浏览次数:

Time:June 23,13:00-14:00

Location:CBIR meeting room 104

Speaker:Anna V. Naumova, Ph.D

Abstract

Cardiac regeneration based on transplantation of stem cell derivates is a rapidly developing area of research with high potential for clinical applications. We have shown that transplantation of human embryonic stem cell derived cardiomyocytes after myocardial infarction in small and large animals leads to remuscularization and concomitant ingrowths of neovasculature. Non-invasive detection of transplanted cells in damaged organs and longitudinal follow up of cell fate and graft size is important for evaluation of cell therapies. This talk will discuss state-of-the-art methods of transplanted cell labeling and visualization using non-invasive imaging. Advantages and disadvantages of direct and indirect (genetic) cell labeling methods will be discussed with the underlying theory and specific applications.

Biographical Sketch

Anna Naumova has obtained her PhD degree at the Institute of Cardiology, Tomsk, Russia.  Dr. Naumova studied metabolism and contractile function of the heart using MRI and spatially localized MR spectroscopy during her postdoctoral fellowship at the JohnsHopkinsUniversity (Baltimore, MD, USA).  Dr. Naumova has joined Vascular Imaging Laboratory (leaded by Chun Yuan, Ph.D.) at the University of Washington (Seattle, WA, USA) in 2005 as a postdoctoral fellow and became a faculty at the Department of Radiology in 2010.  In collaboration with Charles Murry (Department of Pathology, University of Washington) Dr. Naumova is studying myocardium regeneration using human embryonic stem cell derived cardiomyocytes.  Her research interests are focuses on developing novel genetically-based MRI reporters to study transplanted cell fate and function.  Dr. Naumova received several awards for her accomplishments in science and as a speaker.